Connecting Ca2+ and Lysosomes to Parkinson Disease
نویسندگان
چکیده
منابع مشابه
A systematic review on risk factors and protective factors related to Parkinson\'s disease
Background: Parkinson's disease is one of the chronic neurological diseases. It is the second most common neurodegenerative disease after Alzheimer's, affecting 7.5 million people worldwide and its rate is expected to increase by 20% by 2020. three symptoms of tremor, muscle st...
متن کاملImaging approaches to Parkinson disease.
Parkinson disease (PD) is associated with nigral degeneration and striatal dopamine deficiency. Demonstrating midbrain structural abnormalities with transcranial sonography or diffusion-weighted MRI or showing striatal dopamine terminal dysfunction with PET or SPECT supports the diagnosis and rationalizes the use of dopaminergic medications. In atypical PD variants, transcranial sonography can ...
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Background: Parkinson's disease as a progressive disorder of the nervous system leads to the disability of postural control system. Objectives: In the present study the effects of Pilates exercises on functional balance in patients with Parkinson's was investigated. Materials and Methods: This control trial included 30 patients with idiopathic Parkinson's disease who were selected as subj...
متن کاملProfessional exposure to pesticides and Parkinson disease.
OBJECTIVE We studied the relation between Parkinson disease (PD) and professional exposure to pesticides in a community-based case-control study conducted in a population characterized by a high prevalence of exposure. Our objective was to investigate the role of specific pesticide families and to perform dose-effect analyses. METHODS PD cases (n = 224) from the Mutualité Sociale Agricole (Fr...
متن کاملRapid Recycling of Ca2+ between IP3-Sensitive Stores and Lysosomes
Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles. Bafilomycin A1, which prevents lysosomal Ca2+ uptake by inhibiting H+ pumping into lysosomes, increased the amplitude of the initial Ca2+ signals evoked by carbachol in human embryonic kidney (HEK) cell...
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ژورنال
عنوان ژورنال: Messenger
سال: 2016
ISSN: 2167-955X
DOI: 10.1166/msr.2016.1059